TOPLINE:
The usage of bisphosphonates, specifically risedronate, in sufferers with osteoporosis is related to a better chance for acute attitude closure however now not open-angle glaucoma.
METHODOLOGY:
- Researchers carried out a retrospective cohort find out about the usage of a national well being claims database to evaluate whether or not the usage of oral or intravenous bisphosphonates greater the danger for acute attitude closure and open-angle glaucoma.
- A complete of 208,111 sufferers with osteoporosis from america who used bisphosphonates or raloxifene (selected because the reference drug) from 2010 to 2018 have been integrated.
- Sufferers with acute attitude closure and open-angle glaucoma have been recognized the usage of diagnostic codes; sufferers with out those diagnoses have been designated because the regulate workforce.
- The research for acute attitude closure integrated 372 sufferers with the analysis and 1488 sufferers within the regulate workforce (imply age, 70.4 years; imply follow-up, 2.9 years), and the research for open-angle glaucoma concerned 3184 sufferers with the analysis and 12,736 sufferers within the regulate workforce (imply age, 71.5 years; imply follow-up, 2.7 years).
TAKEAWAY:
- Bisphosphonate customers had a better chance for acute attitude closure than nonusers (adjusted prevalence charge ratio [aIRR], 1.78; 95% CI, 1.05-3.01).
- Risedronate customers have been at a better chance for growing acute attitude closure than the ones the usage of different bisphosphonates (aIRR, 2.12; 95% CI, 1.17-3.87).
- Sufferers who have been prescribed risedronate greater than a mean of 5 prescriptions within the 12 months earlier than the development have been at a better chance for acute attitude closure than the ones the usage of different bisphosphonates (aIRR, 2.76; 95% CI, 1.11-6.90).
- No vital affiliation used to be discovered between use of a bisphosphonate and open-angle glaucoma.
IN PRACTICE:
“The consequences from our find out about may have necessary public well being implications as hundreds of thousands of sufferers world wide use bisphosphonates for osteoporosis remedy,” the authors of the find out about wrote. “Physicians prescribing bisphosphonates must talk about the danger of AAC [acute angle closure] with their sufferers when reviewing the facet impact profile and likewise inquire on the usage of bisphosphonates when comparing sufferers with AAC,” they added.
SOURCE:
The find out about used to be led by means of Bonnie He, of the Division of Ophthalmology and Visible Sciences at Dalhousie College, Halifax, Nova Scotia, Canada. It used to be printed online on December 27, 2024, in Eye.
LIMITATIONS:
The constraints of the find out about integrated loss of get admission to to diagnostic data, equivalent to intraocular power or field of regard assessments, which may have affected the evaluate of glaucoma severity. The find out about additionally lacked energy to evaluate other dosages of bisphosphonates and confronted uncontrollable confounders, equivalent to frame mass index and race. The overall apply database used would possibly not have coded predisposing elements, equivalent to hyperopia and myopia. The knowledge have been gathered from a pattern of the inhabitants, which might prohibit the generalizability of the findings to a broader inhabitants.
DISCLOSURES:
The find out about used to be supported by means of the Glaucoma Analysis Society of Canada Undertaking Grant. The authors declared no competing pursuits.
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